Colchester United have now gone eight games without a win and are stuck in the relegation zone after Blackpool completed a quick-fire league double over them at Layer Road.
And the U's had suffered a 3-1 defeat at Bloomfield Road last month, and they were again undone by the Seasiders as two second-half goals left the Essex club deep in trouble.
Blackpool broke the deadlock on 51 minutes. Scott Taylor was twice denied by smart saves from keeper Simon Brown, but when the loose ball flew across the six-yard box home skipper Scott Fitzgerald was unable to get out of the way.
The ball flew off Fitzgerald's chest for an own goal with Blackpool striker John Murphy in close attendance.
Blackpool made the game safe thanks to a wonder strike from Danny Coid in the 69th minute. He benefited from a very slack free-kick by Karl Duguid, who gave possession away.
Suddenly Coid was bearing down on goal and he let fly with a 20-yard shot that flew into the roof of the net via the inside of the far post to put Blackpool two up and effectively out of sight.
Colchester's misery was complete when Duguid was sent off for a second bookable offence on 81 minutes.
Duguid, who had been booked earlier in the second half for dissent, was shown a second yellow and following red card after chopping down goalscorer Coid.
It was certainly not the way that wing-back Duguid would like to have celebrated what was his 250th game in a Colchester shirt.
United had two debutants on display. Liam Chilvers, signed on loan from Arsenal, impressed in a three-man central defence, although striker Gareth Williams, signed on loan from Crystal Palace, lacked service up front.
The Essex side had just one real chance to find a way back into the game when substitute Simon Atangana's ferocious drive was blocked by keeper Phil Barnes.
Kemal Izzet followed up with the rebound but defender Simon Grayson was on hand to hack off the goal-line.
United have now collected just two points from a possible 21 but manager Steve Whitton insisted: "We've got to all stick together and I am sure we can get out of this, although it will be hard.
"We need the support of our fans, something that we didn't really get here." Blackpool manager Steve McMahon said: "At times it felt like I was watching a pre-season friendly.
"To be frank I was bored at times, but I'll settle for these sorts of performances if we get the right result."